Lowering carbon emissions from road-based transport is required to achieve climate targets. In addition to passenger cars, long-haul trucks contribute more than one-third of on-road generated carbon emissions. Therefore, this sector has great potential to reduce such emissions. Numerous options including electrified drivetrains are possible. Nevertheless, the existing fleet of trucks powered by conventional diesel engines also needs to be addressed. Additionally, a ramp-up of green electricity and charging infrastructure is required to ensure carbon-neutral and reliable transport. Heavy-duty diesel engines are typically suitable for use with first-generation biofuels. However, operational restrictions, such as shorter oil drain intervals are mandatory for users. In the case at hand, the oil change was mandatory after only 30,000 km when pure biodiesel (B100) was used instead of 120,000 km when operating on conventional, mineral oil-based diesel. These boundaries counter efforts to