Gearbox synchronizers are essential components for ensuring smooth gear shifting in both manual and automated manual transmissions. The lifespan of a synchronizer is influenced by a complex interplay of several factors, including synchro geometry, lubrication, friction material properties, clutch design parameters, powertrain vibrations, and various operating conditions. These factors contribute to the wear and degradation of synchronizers over time, affecting the overall performance and durability of the transmission system. This paper investigates the influence of various design and operational parameters on the synchronizer's life using a Design of Experiments (DOE) approach. A comprehensive experimental plan was meticulously developed to systematically vary key factors such as synchronizer friction material, the number of cones, lubricant viscosity, and clutch stiffness, among others. The resulting experimental data was analyzed through statistical methods, particularly regression