We report on a technical project that interfaced the National Advanced Driving Simulator (NADS) with SynChrono, a module of the Project Chrono open source platform, to enable real-time, physics-based simulation of multiple autonomous vehicles (AVs). In this setup, a driver at NADS, at the University of Iowa, participates in a traffic scenario that involves AVs that run at the University of Wisconsin-Madison on a cluster supercomputer. The NADS simulator is a driving simulator giving the “most realistic driving simulation experience in the country”. Thanks to its actuators, it can move across its 64-foot by 64-foot bay, rotate and tilt, to emulate vehicle movement and vibrations. In addition, the human driver drives in a full-size cab, surrounded by LED monitors, resulting in an immersive, high fidelity driving simulation experience. SynChrono draws on the Chrono::Vehicle module for detailed vehicle dynamics simulation, providing simulation of vehicle subsystems and tire models