The present study experimentally investigates the effect of engine load and fuel premixing ratio (PMR) on unregulated emission from methanol-diesel dual-fuel RCCI (MD-RCCI) engines. The study focuses on assessing the adverse effects of unregulated emissions (saturated HC, unsaturated HC, carbonyl compounds, aromatic hydrocarbon NH3 and SO2) on the environment and human health. In order to quantify the effect on the environment, the greenhouse gas potential (GWPs), Acidification potential (AP), Eutrophication potential (EP), and Ozone forming potential (OFP) are calculated and presented. To see the effect on human health, the cancer risk potential (CR) of the carbonyl compounds (HCHO and CH3CHO) is calculated and presented. The results demonstrate that at lower engine load, with an increase in PMR the OFP and CR for MD-RCCI operation increase significantly, whereas AP, EP and GWPs decrease. Additionally, with an increase in engine load at a fixed PMR, the AP, EP, and OFP decrease