This paper examines the challenges and opportunities in homologating AI-driven Automated Driving Systems (ADS). As AI introduces dynamic learning and adaptability to vehicles, traditional static homologation frameworks are becoming inadequate. The study analyzes existing methodologies, such as the New Assessment/Test Methodology (NATM), and how various institutions address AI incorporation into ADS certification. Key challenges identified include managing continuous learning, addressing the "black-box" nature of AI models, and ensuring robust data management. The paper proposes a harmonized roadmap for AI in ADS homologation, integrating safety standards like ISO/TR 4804 and ISO 21448 with AI-specific considerations. It emphasizes the need for explainability, robustness, transparency, and enhanced data management in certification processes. The study concludes that a unified, global approach to AI homologation is crucial, balancing innovation with safety while addressing ethical