In order firstly to reduce weight, packaging and cost of engine cooling system and secondly to reduce fuel consumption and pollutants in the exhaust we have seen, over the last twenty years, several innovative engine cooling system offers. These innovative engines cooling were: Nucleate boiling engine cooling, THEMIS™ cooling system, Precision cooling system, Intelligent cooling System, …, CoolMaster™ UltimateCooling™ For each cooling system several vehicles were tested in the climatic wind tunnel, on road in real conditions and on fuel consumption and pollution facilities. The comparison of these innovative engine cooling systems will be presented in this paper, in terms of: System weight, packaging and cost, Fuel consumption and pollutants in the exhaust, Thermal comfort, Heat performance of engine cooling system.