Technique can be used to distinguish between commercial nuclear reactor fuel cycles, fuel cycles for weapons grade plutonium, and products from nuclear weapons explosions. Defense Threat Reduction Agency, Fort Belvoir, Virginia The objective of this work is to identify isotopic ratios suitable for analysis via mass spectrometry that distinguish between commercial nuclear reactor fuel cycles, fuel cycles for weapons grade plutonium, and products from nuclear weapons explosions. Methods will also be determined to distinguish the above from medical and industrial radionuclide sources. There are many sources for radionuclides in our environment. These include natural sources, the commercial nuclear industry, nuclear weapons, the medical industry, and other sources. Often times, the source of the radionuclide may be determined through just identification of the radionuclide. If radionuclides are produced through different sources, the identification of the source is complex. In order to