The goal of this study was to evaluate the effect of environmental conditions, and particular of ambient temperature, on fuel efficiency. Data from various and extensive operational testing were analyzed, such as tests conducted with four groups of medium and heavy-duty vehicles, involved in regional transport, local transport, pick-up and delivery, and urban transport (school bus). The tests were conducted over 5 months of warm season followed by four months of cold season. Other operational testing was conducted over one year in two different geographic and climatic regions in Canada. Data from extensive track testing conducted based on the SAE J 1321 Fuel Consumption Test Procedure-Type II, with various vehicles in different test condition, from spring to winter, was also analyzed. In this type of tests, a control vehicle is used for the base trial, as well as the final trial. As there is no change on the control vehicle, only the environmental conditions impact the fuel consumption