An animal experimental study of the repetitive traumatic brain injury cumulative effect for better pedestrain protection
2022-01-1053
03/29/2022
- Event
- Content
- Acute repetitive brain injury (rTBI) can occur in a pedestrian collision when the head hits the vehicle and the ground twice in a short period of time. In this paper, an animal model of acute rTBI was established to investigate the cumulative effects of repetitive brain injury under different combinations of impact levels. 117 adult male SD rats (190±20g) were divided into control, single impact and repeated impact groups, with the single impact group divided into three subgroups of mild, moderate and severe, and the repeated impact group divided into nine subgroups by combining mild, moderate and severe, and kinematic response parameters of the rat's head were obtained by high-speed camera and acceleration sensor. Modified neurological severity score (mNSS) was performed at 1h, 3h and 6h after injury; brain magnetic resonance imaging (MRI) was detected at 6h after injury. Brain tissue was assessed macroscopically and the severity of injury was quantified using the abbreviated injury scale (AIS).The results showed that cumulative effects of rTBI were not simply linearly superimposed and there was a clear threshold of injury. As a conclusion, an animal model of acute rTBI was successfully constructed, and the cumulative effects of acute rTBI were preliminary discussed, which can provide a reference for the biomechanical mechanism and protection of brain injury in road traffic accidents.
- Citation
- Li, K., Wang, P., Song, X., Qiu, J. et al., "An animal experimental study of the repetitive traumatic brain injury cumulative effect for better pedestrain protection," SAE Technical Paper 2022-01-1053, 2022, .